Sweet Talk In The Brain: Glucosensing, Neural Networks, and Hypoglycemic Counterregulation. MAP kinases couple hindbrain-derived catecholamine signals to hypothalamic adrenocortical control mechanisms during glycemia-related challenges. Salt-inducible kinase is involved in the regulation of corticotropin-releasing hormone transcription in hypothalamic neurons in rats. Lui, Y., Poon, V., Sanchez-Watts, G., Watts, A.Dehydration-anorexia derives from a reduction in meal size, but not meal number. The distribution of messenger RNAs encoding the three isoforms of the Transducer Of Regulated CREB Activity (TORC) in the rat forebrain. G., Sanchez-Watts, G., Liu, Y., Aguilera, G. In “Hormones, Brain, and Behavior, Vol 1.”. Energy Partitioning, Ingestive Behavior and Reproductive Success. Neuroendocrine Regulation of Food Intake. The techniques we use include: whole animal physiology, in situ hybridization, immunocytochemistry (with confocal and conventional immunofluorescence), tract-tracing, behavioral analysis, and neuroinfomatics. The goal here is to understand the structure and functional interactions between the neural systems that inhibit and stimulate feeding, particularly between the cortex, hypothalamus, and hindbrain. The second project investigates the neural basis of anorexia using dehydration as a physiological challenge. We investigate the way that catecholaminergic neurons and glucocorticoids affect signal transduction and gene regulatory mechanisms in sets of forebrain neurons. These neurons are crucial for detecting and encoding information about blood glucose levels. A major focus is on sets of hindbrain catecholaminergic neurons that project to the forebrain. We are interested in how glucocorticoids and neurotransmitters interact with neurons in the hypothalamic paraventricular nucleus, which is a major integrative cell group for metabolic control. In particular, we are interested in the way that two critical metabolic signals-glucocorticoid hormones and hypoglycemia-are sensed by the brain, and then generate appropriate counter-regulatory responses. The first project investigates how peripheral metabolism interacts with the brain to generate adrenocortical and sympathoadrenal hormonal responses. We do this in two projects that focus on the neural control of energy metabolism. Our work is directed towards understanding how the brain contributes to the development, manifestation, and complications of diabetes and obesity. USC-Huntington Early Modern Studies Institute Shinso Ito Center for Japanese Religions and Culture Max Kade Institute for Austrian-German-Swiss Studies Huntington-USC Institute on California and The West Casden Institute for the Study of the Jewish Role in American LifeĬenter for Islamic Thought, Culture and PracticeĬenter for Latinx and Latin American Studies
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